P01-020 – Starting time of inflammatory attacks in patients

Introduction Familial Mediterranean fever (FMF), the most common of the hereditary autoinflammatory diseases, is characterized by recurrent self-limiting attacks of fever and/ or serositis accompanied with acute phase response. Recurrence of attacks does not show a clear periodicity, and its timing is usually unpredictable. Little is known about the factors triggering or precipitating the attacks, and some patients describe physical or emotional exertion, menstrual cycle and dietary changes as possible triggers of the attacks. In other hereditary autoinflammatory disorders, a diurnal variation for the attack was observed with a tendency to experience attacks during evening or night. Recent data suggest that expression of some genes may show a circadian rhythm and affect the immune system, especially innate immune response.